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Well-known Elements in PI3K/Ark/mTOR inhibitor Series

PI3K

LY294002

CAS No. 154447-36-6

LY294002 is definitely the original artificial molecule demonstrated to stay away from PI3Kα/δ/β with IC50 of .5 μM/.57 μM/.97 μM in portable-charge-totally free assays, respectively considerably more constant in response than Wortmannin, as well as disables autophagosome design.

Akt

Perifosine

CAS No. 157716-52-4

Perifosine (KRX-0401) might be a new Akt inhibitor with IC50 of 4.7 μM in Millimeters.1S mobile fabric, objectives pleckstrin homology website name of Akt. Time period 3.

mTOR

Everolimus

CAS No. 159351-69-6

Everolimus (RAD001) is certainly an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a mobile-cost-totally free assay.

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