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Preferred Components in Epigenetics Brochure

Histone Methyltransferase

EPZ004777

CAS No. 1338466-77-5

EPZ004777 is definitely a effective, critical DOT1L inhibitor with IC50 of .4 nM inside a mobile-charge-cost-free of charge assay.

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I-BET151

CAS No. 1300031-49-5

I-BET151 (GSK1210151A) can be quite a specific particular Bet inhibitor for BRD2, BRD3 and BRD4 with IC50 of .5 μM, .25 μM, and .79 μM in cellular-free of charge assays, correspondingly.

DNA Methyltransferase

SGI-1027

CAS No. 1020149-73-8

SGI-1027 can be quite a effective and vital inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, correspondingly.

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