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GSK-3 inhibitor

Ihibitors

Rock and roll inhibitor

Y-27632 2HCl Substance ConstructionY-27632 dihydrochlorideDiscover More>>

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, reveals>200-fold selectivity over other kinases, including PKC, camping-based proteins kinase, MLCK and PAK.

Related Merchandise: Thiazovivin, Fasudil (HA-1077) HCl

GSK-3 inhibitor

CHIR-99021 (CT99021) Chemical substance FrameworkCHIR-99021Discover More>>

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, and that is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM capacity to distinguish between GSK-3 along with its nearest homologs Cdc2 and ERK2.

Relevant Goods: SB216763 , CHIR-98014

Proteasome Inhibitor

MG-132 Chemical substance ConstructionMG-132Discover More>>

Milligrams-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.

Connected Products: Carfilzomib (PR-171) , ONX-0914 (PR-957)

HDAC Inhibitor

Romidepsin (FK228, Depsipeptide) Chemical FrameworkRomidepsin (FK228, Depsipeptide)Find Out More>>

Romidepsin (FK228, depsipeptide) is really a effective HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.

Associated Merchandise: Entinostat (MS-275) , Trichostatin A (TSA)

Akt Inhibitor

MK-2206 2HCl Substance StructureMK-2206 2HClDiscover More>>

MK-2206 2HCl can be a highly discerning inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory pursuits against 250 other health proteins kinases witnessed. Stage 2.

Connected Merchandise: AZD5363 , GDC-0068

Raf Inhibitor

Vemurafenib (PLX4032, RG7204) Compound StructureVemurafenibLearn More>>

Vemurafenib (PLX4032, RG7204) can be a unique and strong inhibitor of B-RafV600E with IC50 of 31 nM.

Related Items: Sorafenib Tosylate , PLX-4720

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