(+)-JQ1 is really a Option bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in mobile phone-cost-free assays, binding to any or all bromodomains from the Wager family, although not to bromodomains away from Option family.
Associated Goods: GSK6853, CPI-637
CHIR-99021 (CT99021) can be a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.
Relevant Products: TDZD-8 , SB 216763
PD98059 is really a non-ATP competing MEK inhibitor with IC50 of 2 μM in the mobile-free of charge assay, particularly inhibits MEK-1-mediated activation of MAPK is not going to directly inhibit ERK1 or ERK2.
Related Items: GDC-0623 , APS-2-79
Forskolin is a all-pervasive activator of eukaryotic adenylyl cyclase (AC) in numerous mobile phone varieties, popular to increase degrees of camp out inside the research and analysis of mobile phone physiology.
Associated Products: Isoprenaline hydrochloride
Potent and picky G9a/GLP histone lysine methyltransferase inhibitor (IC50= 3.3 nM).
Connected Items: DIM-C-pPhOH , CCT241736
45 varieties of compound libraries for high throughput testing and content material evaluating.
DNA Problems/DNA Fix
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