There are several diseases caused by microbial infection while others are caused due to disregulation of primary metabolic and body defense systems, which are evolved to protect body from suffering.There are many examples, where plant products have made their irony contribution toward disease management. In, another antimalarial drug called chloroquine was synthesized and used for the treatment of malaria; however, due to their synthetic origin, the pathogen develops resistance, which was more problematic. Generally, it is evident that the diabetic people have more chances of cardiovascular attacks than the nondiabetic ones. Up to now only plasmamediated transfusion of drugs are available to treat diabetes due to their sensitivity toward digestive enzymes, which inactivates them upon consumption when taken through oral routes; therefore, it is desirable to think toward some oral form of alternatives.In this context, plants can be the best alternatives, and more than plants are available and reported to show antidiabetic properties without causing any complication. Stevia rebaudiana, which was reported to be more than hundred times sweeter than the sugar, possesses hypoglycemic action in diabetic patients. The possible mechanism of action of taxol was believed to occur due to arrest of cells in GM phase of the cell cycle, while camptothecin exhibits their action by inhibiting the activity of topoisomerase I enzymes involved in DNA replication. Several other compounds like topotecan, irinotecan, docetaxel, podophyllotoxin, teniposide, and elliptinum have been documented to showed anticancerous properties. The antiretroviral therapy is the most signicant approach used for their treatment, and it is recommended that all patients with detectable HIV infection should be treated with antiretroviral therapy to prevent their subsequent progression as well as to reduce transmission. Galanthus nivalis performed its action by preventing the binding of viral envelop protein to the host cells receptor, therefore inhibiting hostspecic recognition. The important disease caused by bacteria include diarrhea, tuberculosis, typhoid, and many more, while fungi caused mycotoxicosis, which is characterized by immune suppression, liver cirrhosis, abnormal fetus development, stunted growth, and sometimes cancers. Different chemical preservatives and shelf life enhancers have been used since long time to eradicate these contaminants and their toxins; however, their indiscriminate use may lead to the development of resistance stain of these contaminants and residual toxicity to the nontarget organisms and to the environments. In this context, many authors have claimed the importance of plantderived essential oils and their bioactive compounds as safer candidate for the preservation of these food items.In the last two decades, herbal formulations have been proven to act as effective strategies, and many plant bioactive compounds, namely, epigallocatechin gallate from tea, quercetin from onion and apple, acacetin from black locust, and genistein from bean plants have been proved to have antiviral and hepatoprotective properties. None of the medicines discovered till date have been reported to completely reverse multiple sclerosis; however, sometimes it is believed that the utilization of plantderived compounds can be the effective strategies, and this may restore the functioning of neurons inammation.In this regard, some important plants and their derivatives have been used and reported by many workers against multiple sclerosis.