Cyclopamine Ingredient DevelopmentCyclopamine
Cyclopamine is definitely a a variety of Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells.
Study emphasize: Connection with cyclopamine endorses pancreatic growth in embryonic women. (Kim SK, et,al. PNAS, 1998, 95: 13036-13041.)
This product can be purchased in : Bioactive Substance Catalogue, All-organic and natural Element Neighborhood library
TWS119 Compound ConstructionTWS119
TWS119 is actually a GSK-3β inhibitor with IC50 of 30 nM in the mobile phone-totally free assay effective at inducing neuronal differentiation and will even be appropriate to originate cell phone biology.
Evaluation tension: TWS119, a 4,6-disubstituted pyrrolopyrimidine that may lead to neurogenesis in murine ESCs. (Ding S, et,al. PNAS, 2003，100(13): 7632-7637. )
The item consists of in : Bioactive Chemical Selection
Nicotinamide Compound chemical Platform Nicotinamide
Nicotinamide (Supplement B3), a h2o-soluble supplement dietary supplement nutritional supplement, is without a doubt an vibrant element of coenzymes NAD and NADP, and also act as an activator of sirtuins.
Evaluation focus: nicotinamide much better the create of differentiation of Embryonic Show up Muscle to pancreatic endocrine muscle tissues (Lumelsky N,et,al.Investigation, 2001, 292(5520): 1389-1394 )
This piece of equipment contains in : Approved Drug Library, Regular Chemical substance Collection
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Includes 3071 little molecule compounds
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Features 640 organic compounds
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