TargetMol’s hot-marketing inhibitors for the selection.
Vemurafenib (PLX4032, RG7204) could be a impressive and strong inhibitor of B-RafV600E with IC50 of 31 nM.
Olaparib (AZD2281, KU0059436) is actually a distinct inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-functions less efficient against tankyrase-1. Time period 3.
Rapamycin (Sirolimus, AY-22989, WY-090217) can be quite a specific mTOR inhibitor with IC50 of ~.1 nM.
4. Ibrutinib (PCI-32765)
Ibrutinib (PCI-32765) is actually a highly effective and highly discerning Brutons tyrosine kinase (Btk) inhibitor with IC50 of .5 nM, modestly effective to Bmx, CSK, FGR, BRK, HCK, a lot less powerful to EGFR, Needless to say, ErbB2, JAK3, and so on.
Trametinib (GSK1120212) is in reality a highly distinct and potent MEK1/2 inhibitor with IC50 of .92 nM/1.8 nM, no inhibition inside the kinase activities of c-Raf, B-Raf, ERK1/2.
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