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Popular-advertising Inhibitors

Rock and roll inhibitor

Y-27632 dihydrochloride

Y-27632 dihydrochloride is truly a specific ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits>200-collapse selectivity over other kinases, for example PKC, camping out-reliant healthy proteins kinase, MLCK and PAK.

Pertinent Merchandise: Thiazovivin, Fasudil (HA-1077) HCl

GSK-3 inhibitor

CHIR-99021

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, and that is certainly a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM capability to independent GSK-3 along with its closest homologs Cdc2 and ERK2.

Relevant Goods: SB216763 , CHIR-98014

Proteasome Inhibitor

MG-132

MG-132 is undoubtedly an inhibitor of proteasome with IC50 of 100 nM, and likewise inhibits calpain with IC50 of 1.2 μM.

Hooked up Goods: Carfilzomib (PR-171) , ONX-0914 (PR-957)

HDAC Inhibitor

Romidepsin (FK228, Depsipeptide)

Romidepsin (FK228, depsipeptide) might be a powerful HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, correspondingly.

Associated Goods: Entinostat (MS-275) , Trichostatin A (TSA)

Akt Inhibitor

MK-2206 2HCl

MK-2206 2HClis actually a highly certain inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory activities against 250 other healthy healthy proteins kinases seen. Phase 2.

Hooked up Products: AZD5363 , GDC-0068

Raf Inhibitor

Vemurafenib

Vemurafenib (PLX4032, RG7204) is really a distinctive and powerful inhibitor of B-RafV600E with IC50 of 31 nM.

Related Items: Sorafenib Tosylate , PLX-4720

Piece Catalog

Substance Catalogue

32 forms of chemical libraries for high throughput assessing and high information and facts affirmation.

Investigation Regions

Proteases/Proteasome

Chromatin/Epigenetic

JAK/STAT Signaling

Tyrosine Kinase/Adaptors

PI3K/Akt/mTOR Signaling

MAPK Signaling

Apotosis

Ubiquitination

Angiogenesis

Immunology/Irritation

DNA Injury/DNA Restoration

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