Rock and roll inhibitor
Y-27632 dihydrochloride is truly a specific ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits>200-collapse selectivity over other kinases, for example PKC, camping out-reliant healthy proteins kinase, MLCK and PAK.
Pertinent Merchandise: Thiazovivin, Fasudil (HA-1077) HCl
CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, and that is certainly a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM capability to independent GSK-3 along with its closest homologs Cdc2 and ERK2.
Relevant Goods: SB216763 , CHIR-98014
MG-132 is undoubtedly an inhibitor of proteasome with IC50 of 100 nM, and likewise inhibits calpain with IC50 of 1.2 μM.
Hooked up Goods: Carfilzomib (PR-171) , ONX-0914 (PR-957)
Romidepsin (FK228, Depsipeptide)
Romidepsin (FK228, depsipeptide) might be a powerful HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, correspondingly.
Associated Goods: Entinostat (MS-275) , Trichostatin A (TSA)
MK-2206 2HClis actually a highly certain inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively no inhibitory activities against 250 other healthy healthy proteins kinases seen. Phase 2.
Hooked up Products: AZD5363 , GDC-0068
Vemurafenib (PLX4032, RG7204) is really a distinctive and powerful inhibitor of B-RafV600E with IC50 of 31 nM.
Related Items: Sorafenib Tosylate , PLX-4720
32 forms of chemical libraries for high throughput assessing and high information and facts affirmation.
DNA Injury/DNA Restoration
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